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Thyroid Antibodies and Pregnancy Loss
Title:Thyroid autoantibodies are not associated with recurrent pregnancy loss
Author: M. Esplin et al.
Address: Salt Lake City Utah
Source:
American Journal of Obstetrics and Gynecology: 179: 1583-1586 (December) 1998
Summary: The objective of this study was to determine whether circulating autoantibodies
were associated with recurrent pregnancy loss. 74 nonpregnant women with a history of recurrent
pregnancy loss and 75 controls of similar gravidity were tested for thyroglobulin and thyroid peroxidase
antibodies and 3rd generation TSH . The blood samples were obtained 6 months after a pregnancy. Positive
results for either one, or both, thyroid autoantibodies occurred in 22 (29.3%) of the women with a history
of recurrent pregnancy loss and 28 (37%) of the control subjects. Mean TSH levels did not differ between
the 2 groups. It was concluded that women with recurrent pregnancy loss are no more likely to have circulating
thyroid autoantibodies than fertile control subjects. Testing for their presence is not clinically useful.
Comment: It is still useful to check a TSH level in all patients with ovarian dysfunction,
although it is reassuring to note that autoantibodies do not interfere with pregnancy. It has been feared
that patients with autoantibodies, although treated, have a higher incidence of pregnancy loss.
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