Also see Fact
Sheet - Early
Pregnancy and Pregnancy Loss
Is infertility inherited?
Trisomy 18
Question:
I am 25 years old, 5ft. 4in, 140lbs, and I consider myself
healthy. I conceived my child without fertility drugs, but
it took over 4 years, and happened after I gave up! Now I’m
trying for #2 with no luck. This time I am charting basal
body temperature, cervical mucous, using ovulation predictor
kit, and Clomid. I am not ovulating on 100mg.I have no egg
white cervical mucous. I have an LH-surge but no temperature
rise. My mother had trouble conceiving. It took her 5 years
for #1, 3yrs for #2. Then after that she had one almost every
year until there were 9 of us. It took my two sisters 3 and
8 years to get pregnant and it took me 4.Why are we all infertile?
Is this a coincidence? Or could this be hereditary? My cousins
do not seem to have problems so what is wrong with us?
Comment:
Sounds like it runs in the family to me. Patterns of ovarian
function are often hereditary and may "come down"
on either the mother’s or dad's side. The most common
type of ovulatory dysfunction is associated with polycystic
ovaries and is definitely family related. You should try to
learn more about PCOS, perhaps over the Internet and sees
if the diagnosis fits. There are some new options for treatment
of PCOS other than clomiphene and injections. If clomiphene
is not successful, you may need to progress to injectable
fertility drugs. SST
Question:
I got pregnant with my son in 3 months; however, it has taken
us 2 years to get pregnant again. I did get pregnant once
only to find out that baby had Trisomy 18. I lost the baby
three months later and then had a subsequent D & C. What
are the chances of Trisomy 18 happening again? Will it most
likely take another 2 years to get pregnant again? How aggressive
should we be? I usually don't ovulate until day 22 or 23 on
a 31day cycle. Is my luteal phase too short? What can be done
about this?
Comment:
It is not a luteal phase defect, but a follicular phase defect
(delayed ovulation) that is the most likely reason for the
pregnancy loss. We know that ovulation past day 14 is associated
with a greater chance of infertility and pregnancy loss. I
would look for the common theme between your inability to
conceive and the pregnancy loss. I would think it might be
altered ovulation. I believe that ovulation after cycle day
2 16 leads to a greater chance of genetic problems and pregnancy
loss. Sometimes clomiphene will help with an ovulation problem.
Overall the chance of recurrence is probably only very slightly
more than others. I would probably not let this deter you,
but if questions remain, a genetic consultation may be in
order. SST
Also see Fact Sheet - Early
Pregnancy and Pregnancy Loss
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