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Gene Transfer to the Uterine Endometrium
Title:In vivo gene transfer to the uterine endometrium
Author:Charnock-Jones,DS et al.
Address:Cambridge, England
Source:Human Reproduction 12:17-20, 1997 (January)
Synopsis:Our capacity to modulate uterine function is very basic- hormone replacement (estrogen and progestins), oral contraceptives, anti-steroids (Tamoxifen, clomiphene, RU 486), antiprostaglandin agents (ibuprofen, aspirin). Our understanding of reproductive biology has outweighed our therapeutic advances. This Cambridge group has directly transferred specific genes to human endometrium in vitro and mouse endometrium in vivo and offers this as a new approach to regulation of uterine function. Using marker genes, DNA is complexed with lipids to form liposomes. These are taken into epithelial cells avoiding the more common use of viral agents and the possibility of viral recombination. While a "reporter" gene was used by the researchers, the technique possibly can be extended to transfer of genes that could enhance or retard uterine function. There still remains the problems of the cyclic turnover of the endometrium and the availability of the desired genes to transfer. However, this represents the first description of this strategy and a valuable tool for the study of uterine function. It certainly will have far reaching therapeutic implications for improving or preventing implantation, and for medical therapy of diseases only surgically correctable at present.