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Steroid Receptors in the Uterosacral Ligaments
Title: Estrogen and progesterone receptors in the uterosacral ligament
Authors: M.Mokryzycki et al
Address: New York, New York
Source: Obstetrics and Gynecology 90: 396-401 (September) 1997
Summary: The uterosacral-cardinal ligament complex and the levator plate is part of the support of the upper vagina, cervix and uterus . Uterine prolapse has been associated with damage to these structures. This study evaluates the steroid receptor status in the uterosacral ligament, the presence of which may suggest a possible role for steroid hormones in pelvic support. The uterosacral ligaments from 25 consecutive women undergoing hysterectomy for non-malignant conditions were sampled. Using commercially available monoclonal antibodies, estrogen and progesterone receptors were detected in the nuclei of smooth muscle cells of the uterosacral ligament in all patients. This finding was present regardless of variations in age, race, menopausal status, parity, body mass index, and medications affecting serum steroid hormone levels. Estrogen and progesterone receptors were not present in the collagen, vascular, or neuronal components. This finding raises the possibility of estrogen replacement as a preventive as well as a therapeutic modality in the treatment of uterine prolapse.
Comment: As one would anticipate, but interesting nevertheless.