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Choosing the Sex of a Child-A Risky Business
Title:Evaluating sex chromosome content of sorted human sperm samples with use of dual-color fluorescence in situ hybridization
Author: W.E. Richards et al.
Address: Houston, Texas
Source: American Journal of Obstetrics and Gynecology 176: 1172-1180 (June) 1997
Summary: Twelve sperm banks form the US and Canada were contacted as to the availability of X or Y enriched samples. Four banks had stated the service was available, but only one was willing to release samples for study. Enriched samples were sorted using two sets of X and Y chromosome -specific, fluorophore-labeled deoxyribonucleic acid probes and evaluated for classification of hybridization efficiency, aneuploidy, and sex chromosome content by 3 blinded observers. The authors found a small, but significant, shift in the sex chromosome rations among samples. However, this shift was the opposite that purported by the commercial supplier.
Comment:There was the obstetrician who always correctly predicted the sex of the baby at the first obstetric visit. He would tell the parents one sex and record the opposite in their chart. When born, if the sex was opposite that predicted, he would show the couple the record. Then, there was the billionaire from the Middle East who offered the IVF program $2 million for an absolute guarantee of a male child. Germinated in folklore and propagated by todays sophisticated technology, sex selection remains a favored topic for prospective parents, research laboratories, ethicist and entrepreneurs. Preimplantation diagnosis is very accurate , but requires IVF blastomere biopsy, and is only possible in several labs worldwide and is not offered except to exclude transmission of sex chromosome linked diseases. The separation of X and Y bearing sperm should be possible in the future, but to date no procedure has been shown valid enough for widespread adoption. There are several new techniques that offer promise, but the statistics are not there yet. There is a terrific market force pushing a development of this technology. Let the buyer beware. Worldwide, sex selection, almost exclusively toward males, may prevent the the current practice of abortion of female fetuses and there are ethical arguments for this technology. But in final analysis, even if we can should we?