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Title: Hyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity
Author: K. Mather, et al.
Address: Alberta, Canada
Source: Fertility and Sterility 73: 150-156 (January) 2000
Summary: Researchers studied 57 women with clinically defined polycystic ovarian syndrome (PCOS) and 45 unselected healthy age-matched controls to assess the role of insulin resistance, independent of obesity, in determining cardiovascular risk among women with the PCOS. They studied the relationships between hyperinsulinemia, composite cardiovascular risk scores, and prevalence of individual risk factors. Hyperinsulinemic women with PCOS carried more cardiovascular risk than their normoinsulinemic counterparts, who in turn had more risk than the control women. In addition to the lipid changes expected with insulin resistance, there was an excess of LDL cholesterol among the women with PCOS. Across the range of body mass index, women with PCOS had greater insulin resistance than controls, suggesting that PCOS itself and body mass index both contribute to the observed insulin resistance. Researchers concluded that insulin resistance in PCOS is a determinant of overall cardiovascular risk independent of obesity. However, the mechanism of this relationship remains uncertain.