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Day 3 or day 5 embryo transfers?
Title:The number of eight-cell embryos is a key determinant for selecting day 3 or day 5 transfer
Author: C. Racowsky, et al.
Address: Boston, MA
Source: Fertility and Sterility 73:558-564(March) 2000
Summary: To compare outcomes of day 3 and day 5 transfer, researchers conducted a retrospective analysis of assisted reproduction technology (ART) cycles comparing outcomes. Subjects were 221 patients with day 3 embryo transfers and 141 patients with day 5 transfers. With no eight-cell embryos on day 3, 0% and 33% pregnancies resulted from day 5 vs. day 3 transfers. With one or two eight-cell embryos on day 3, ongoing and high order multiple rates were not different between day 3 and day 5 transfers. With three or more eight-cell embryos, day 5 transfer resulted in a decrease in multiple gestations but no difference in ongoing pregnancy rates compared with day 3 transfer. Researchers concluded that with no eight-cell embryos on day 3, a day 3 transfer is warranted. With one or two eight-cell embryos, any benefit of day 5 transfer appears to be equivocal. With three or more eight-cell embryos, day 5 transfer is recommended. The appropriate application of day 5 transfer maximizes the likelihood of success for all patients while minimizing the possibility of a high-order multiple pregnancy.
Comment: This seems to be a very rational approach.