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Obesity gene
Title:Independent confirmation of a major focus for obesity on chromosome 10
Author: A. Hinney, et al.
Address:Marburg, France
Source:The Journal of Clinical Endocrinology & Metabolism 85:2962-2965 (August) 2000
Summary: Linkage of obesity to chromosome 10p12 with a maximal multipoint LOD score of 4.85 was reported upon use of an affected sib-pair approach including nuclear families in which the adult index case had a BMI greater than or equal to 40kg/m2 and at least one further sibling had a BMI greater than or equal to 27 kg/m2. In an effort to reproduce this linkage finding, researchers genotyped 11 markers spanning approximately 23 cm from 10p13 to 10q11 in a total of 386 individuals stemming from 93 nuclear families with two or more young obese offspring with a BMI greater than or equal to the 90th age percentile. The highest multipoint maximum likelihood binomial LOD score using the extreme concordant sib-pair approach in which one sib had a BMI greater than or equal to the 95th percentile, and other sibs a BMI less than or equal to the 90th percentile was 2.32. Six markers yielded nominal p-values less than 0.05, the highest two point MLB-LOD score of 2.45 was obtained for the marker TCF8. Transmission disequilibrium tests for the most frequent parental allele yielded no nominal p-value less than 0.05. The linkage results confirm the presence of a major susceptibility locus for obesity in a region near the centromere on chromosome 10.
Comment: Once the (a) gene is found, can it be fixed?