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Mass screening for ovarian cancer
Title:Usefulness of mass screening for ovarian carcinoma using transvaginal ultrasonography
Author: S. Sato, et al.
Address: Hirosaki, Japan
Source: Cancer 89:582-588 (September) 2000
Summary: The intent of this study was to summarize and evaluate screening results for the last 10 years with respect to ovarian carcinoma diagnosis and risk factors. Primary screening by transvaginal ultrasonography (TVS) was performed in 183,034 asymptomatic women who participated in annual uterine cervical carcinoma screening. The time required for primary screening was 1 minute per subject. Women with abnormal sonograms received secondary screening (n=5309) and closer examination with a tumor marker and an imaging diagnostic examination. Laparotomy was conducted on all masses with a greatest dimension of greater than or equal to 60 mm or on suspected malignant masses (n=324). Twenty-two primary tumors and 2 metastatic tumors were detected for a diagnostic rate of 0.047%. Of the 22 primary tumors, 17 were classified as Stage I carcinoma, with tumor markers positive only for 5. The percentage of the total number of stage I ovarian carcinoma cases increased after the induction of screening from 29.7% to 58.8%. Researchers believe these results are significant in that 77.3% of the primary ovarian carcinomas found during the current screening were of curable Stage I. Thus, increased use of TVS screening for ovarian carcinoma may increase the chance for early diagnosis and decrease the mortality of the disease. Furthermore, the screening program yielded no false-positive results.