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Birth weight, body mass index and diabetes risk
Title: Intrauterine insemination or in-vitro fertilization in idiopathic subfertility and male subfertility: a randomized trial and cost-effectiveness analysis
Author: R. Lindsay, et al.
Address: Phoenix, AZ
Source:Diabetes Care 23:1249-1254 (September) 2000
Summary: Researchers hypothesized that, in light of the historical improvements in the management of diabetes during pregnancy, the consequence of offspring of mothers who had diabetes during pregnancy experiencing an increased risk later of diabetes and obesity might be diminishing with time. Birth weight and information of BMI and glucose tolerance were collected as part of an epidemiological survey. Researchers examined this information and diabetes in offspring of mothers with type 2 diabetes during pregnancy born in four ten year time intervals since 1955 and compared with offspring whose mothers either had not developed diabetes or were prediabetic. It was discovered that the offspring of diabetic mothers were heavier at birth, had a higher BMI at all ages throughout childhood, and had an increased incidence rate of diabetes during childhood and as adults. In children born after 1965, despite secular trends to higher BMI and diabetes incidence in the offspring of nondiabetic mothers, differences in BMI and birth weight of offspring of diabetic mothers versus offspring of nondiabetic mothers and offspring of prediabetic mothers appeared to have been maintained. It was concluded that, with the possible exception of those born before 1965, the increased risk of diabetes and obesity experienced by children of diabetic mothers does not seem to be diminishing with time.
Comment: Very important information.