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Infection and
miscarriage
Title:Relationship of bacterial vaginosis
and mycoplasmas to the risk of spontaneous abortion
Author: G.
Donders, et al.
Address: Belgium
Source:American Journal of
Obstetrics and Gynecology 183:431-437 (August) 2000
Summary: Two
hundred twenty-eight women receiving routine prenatal care during the first
trimester and who had a living singleton fetus were examined for microbiologic
flora of the vagina in an effort to discover a link between first-trimester
diagnosis of bacterial vaginosis and cessation of pregnancy at <20 weeks'
gestation. Researchers found that the presence of bacterial vaginosis at the
first prenatal visit was strongly associated with subsequent early pregnancy
loss. After multivariate analysis, bacterial vaginosis, Mycoplasma hominis, and
Ureaplasma urealyticum, but not other microorganisms, remained linked to a
greater risk of miscarriage. It was concluded that bacterial vaginosis and
mycoplasmas may play contributing roles in spontaneous abortion and early
pregnancy loss.
Comment: To culture for these organisms is very
expensive and not very reliable. It is possibly better to treat, but to whom and
when should we give antibiotics.