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OC use and breast cancer risk
Title: Risk of breast cancer with oral contraceptive use in women with a family history of breast cancer
Author: D. Grabrick, et al.
Address: Minnesota, Minneapolis
Source: Journal of the American Medical Association 284:1791-1798 (October) 2000
Summary: Researches wanted to determine whether the association between OC use and risk of breast cancer is influenced by family history of the disease. It was a historical cohort study of 426 families of breast cancer probands diagnosed between 1944 and 1952. Participants were a total of 394 sisters and daughters of the probands, 3002 granddaughters and nieces, and 2754 women who married into the families. Researchers concluded that women who have ever use earlier formulations of OCs and who also have a first-degree relative with breast cancer may be at particularly high risk for breast cancer. However, more studies are needed of women with a strong family history who have used more recent lower-dosage formulations of OCs are needed to determine how women with a familial predisposition to breast cancer should be advised regarding OC use today.
Comment: Donąt sound the alarm yet. No one has ever said that OCs protect against breast cancer, but there is also no evidence that OCs cause breast cancer in much larger studies. This study could be subject to several types of bias and needs confirmation. If the łolder-higer˛ dose OCs had significant increase, we should have seen it before now. As the author admits, the same may not hold for presently used OCs.