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Aspirin and infertility
Title: Low-dose aspirin for infertile women with thick endometrium receiving intrauterine insemination: A prospective, randomized study
Author: Y. Hsieh
Address: Taichung, Taiwan
Source: Journal of Assisted reproduction and Genetics 17:174-178 (March) 2000
Summary: To evaluate the effect of aspirin on infertile women with thin endometrium, 114 women were placed into an aspirin group and 122 women into a nonaspirin group. These subjects had an endometrium £ 8mm and intrauterine insemination. Endometrial pattern and thickness, the pulsatility index and resistance index of the uterine artery, spiral artery, and ovarian dominant follicles, and pregnancy rates of both groups were measured. Significantly higher percentages of trilaminar endometrium (46.5% vs. 26.2%) and pregnancy rate (18.4% vs. 9.0%) after aspirin therapy were noted. Researchers concluded that higher pregnancy rates and better endometrial pattern were achieved in patients with thin endometrium after aspirin administration. However, aspirin therapy could not significantly add to the endometrial thickness and the resistance of uterine and ovarian flow.
Comment: Use of aspirin to improve implantation or prevent miscarriage has been bantered about for a number of years. Theoretically, aspirin could improve circulation by its action on prostacyclin/thromboxane pathways, but its anti-inflammatory action could equally blunt the prerequisite inflammatory response necessary for implantation. The mere fact that most do not use it can be taken as an indication of its lack of effectiveness. I wish someone would perform a definitive well-designed and controlled study to put this issue to rest.