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IVF in women over age 41
Title: Outcome of assisted reproductive technology in women over the age of 41
Author: R. Ron-El, et al.
Address: Zerifin, Israel
Source: Fertility and Sterility 74:471-475 (September) 2000
Summary: This study of 431 IVF and intracytoplasmic sperm injection (ICSI) cycles was designed to analyze the results of ongoing pregnancies and deliveries after assisted reproductive technology in women aged greater than or equal to 41 years. Of the 431 cycles, 87% reached the oocyte retrieval stage. The average number of oocytes aspirated per patient was 5.4 ± 0.9 in the IVF cycles and 6.7 ± 1.2 in the ICSI cycles. In IVF cycles 2.3 ± 1.3 embryos were obtained and the number of these transferable was 2.0 ± 1.2; in the ICSI cycles 2.8 +1.6 embryos were obtained 2.5 ± 0.8 were transferable. The pregnancy rate per oocyte pickup (OPU) was 12.4% but the delivery rate per OPU was only 4.5%. The mean delivery rate per OPU among women 41-43 years was 2%-7%. There were no deliveries in women greater than or equal to 44 years and no pregnancies at the age of 45 years. Researchers concluded that ART performed with homologous oocytes (by IVF or ICSI) produced no clinical pregnancies among women greater than equal to 45 years and no deliveries in women greater than or equal to 44 years. The average delivery rate per oocyte retrieval among women aged 41-43 years varied between 2% and 7%.
Comment: Every time the statistics are figured for women over 41, it just keeps coming up the same. We just do not seem to get any better in treating this group of women, but we keep trying.