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Aspirin, vitamin E, and cardiovascular disease
Title: Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomized trial in a general practice
Author: M. Roncaglioni, et al.
Address: Milan, Italy
Source: The Lancet 357:89-95 (January) 2001
Summary: The intent of this study was to determine in general practice the effectiveness of antiplatelets and antioxidants in primary prevention of cardiovascular events in people with one or more major cardiovascular risk factors. The study was a randomized controlled open 2x2 factorial trial to investigate low-dose aspirin (100 mg/day) and vitamin E (300 mg/day) in the prevention of cardiovascular events, in people with one or more of the following characteristics: hypertension, hypercholesterolaemia, diabetes, obesity, family history of premature myocardial infarction, or individuals who were elderly. The patient group consisted of 4495 people, 2583 of whom were female with an average age of 64.4 years. Researchers found that aspirin lowered the frequency of all the endpoints, being significant for cardiovascular death (from 1.4 to 0.8%) and total cardiovascular events (from 8.2 to 6.3%). However, severe bleedings were more common in the aspirin group than the no-aspirin group (1.1% vs. 0.3%). Vitamin E was found to have no effect on any endpoint. It was concluded that in women and men at risk of having a cardiovascular event because of the existence of at least one major risk factor, low-dose aspirin given as a supplement to treatment of specific risk factors contributes an additional preventive effect, with an acceptable safety profile.
Comment: This confirms other studies on the value of aspirin. Curious about vitamin E.