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CARS Archives

Baby birthweight and health risks for mothers
Title: Birth dimensions of offspring, premature birth, and the mortality of mothers
Author: G. D. Smith, et al.
Address: Bristol, UK
Source: The Lancet 356:2066-2067 (December) 2000
Summary: In a cohort of pregnant Finnish women, researchers evaluated the relationship between birth dimensions of the offspring and maternal characteristics, and subsequent mortality. Maternal all-cause mortality was inversely related to birthweight and birth length of offspring. Cardiovascular disease (CVD) and smoking-related cancer mortality were inversely related to these birth dimensions and also to ponderal index (weight/height3). CVD mortality was also raised among mothers giving birth prematurely. Breast-cancer mortality was positively associated with ponderal index of offspring. Researchers showed a strong association of premature delivery with CVD mortality and no association with mortality from smoking-related cancers, which suggests that confounding by smoking is not responsible for the former association. Case-series data have suggested that women who give birth to large babies are at an increased risk for breast cancer. Maternal insulin-like growth factor-1 concentrations are related to both offspring ponderal index and to breast-cancer risk. Researchers concluded that maternal factors which affect intrauterine growth and premature delivery seem to have important influences on long-term mortality risk in women.
Comment: More research on this interesting topic is needed. Less well established than above.

 

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