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Baby birthweight and health risks for mothers
Title: Birth dimensions of offspring, premature birth, and the mortality of mothers
Author: G. D. Smith, et al.
Address: Bristol, UK
Source: The Lancet 356:2066-2067 (December) 2000
Summary: In a cohort of pregnant Finnish women, researchers evaluated the
relationship between birth dimensions of the offspring and maternal
characteristics, and subsequent mortality. Maternal all-cause mortality was
inversely related to birthweight and birth length of offspring. Cardiovascular
disease (CVD) and smoking-related cancer mortality were inversely related to
these birth dimensions and also to ponderal index (weight/height3). CVD
mortality was also raised among mothers giving birth prematurely. Breast-cancer
mortality was positively associated with ponderal index of offspring. Researchers
showed a strong association of premature delivery with CVD mortality and no
association with mortality from smoking-related cancers, which suggests that
confounding by smoking is not responsible for the former association. Case-series
data have suggested that women who give birth to large babies are at an increased
risk for breast cancer. Maternal insulin-like growth factor-1 concentrations are
related to both offspring ponderal index and to breast-cancer risk. Researchers
concluded that maternal factors which affect intrauterine growth and premature
delivery seem to have important influences on long-term mortality risk in women.
Comment: More research on this interesting topic is needed. Less well
established than above.