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CARS Archives



Post operative danazol of questionable benefit for endometriosis
Title: Effects of 3-month therapy with danazol after laparoscopic surgery for stage III/IV endometriosis: a randomized study
Author: S. Bianchi, et al.
Address: Milano, Italy
Source: Human Reproduction 14(5): 1335-1337 (May) 1999
Summary: Researchers evaluated the effect of treatment with danazol in respect to expectant management after laparoscopic conservative surgery. A total of 77 women >40 years old with unexplained infertility and/or chronic pelvic pain, and laparoscopic surgery undertaken for moderate or severe endometriosis, were included in the study. Women who had undergone treatment for endometriosis or had other diseases that might affect fertility or cause pelvic pain were excluded. Thirty-six patients were randomized to treatment with danazol 600 mg/day for 3 months after surgery and 41 patients were allocated to receive no postoperative treatment. Patients were followed up every 6 months for evaluation of fertility, recurrence of pain symptoms and disease. Six of the 11 infertile women allocated to danazol and 8 of the 16 given no treatment became pregnant. Moderate/severe pelvic pain recurred during follow-up in 7 of the 31 women with pelvic pain allocated to the danazol group and 9 of the 29 allocated to no treatment. Three of the women treated with danazol and 6 who received no treatment had disease recurrence. A 3-month course of danazol after laparoscopic surgery for stage III/IV endometriosis does not markedly improve short-term reproductive prognosis or pelvic pain.
Comment: Unfortunately, the same result would be predicted for Lupron. I am not sure I would have expected to concur with the result, which is why studies are performed. What would the post-operative course be with danazol or Lupron pretreatment?

 

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