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CARS Archives



PCOS in adolescents
Title:Endocrine features of polycystic ovary syndrome in a random population sample of 14 - 16 year old adolescents
Author: M. van Hooff, et al.
Address: Amsterdam, The Netherlands
Source: Human Reproduction 14: 2223-2229 (September) 1999
Summary: This prospective study utilized cross-sectional data on the endocrinology of menstrual cycle disorders from an unselected population of 14 - 16 year old adolescents. Researchers estimated the prevalence of endocrine abnormalities compatible with polycystic ovary syndrome (PCOS) in adolescents with menstrual cycle disorders and investigated whether adolescents with irregular cycles can be reassured that this will be transient, or whether endocrine evaluation should be advised and information provided about a higher probability for subfertility. A total of 2248 girls participated. Blood was taken from 107 adolescents with regular menstrual cycles, 52 with oligomenorrhoea and 4 with secondary amenorrhoea. Oligomenorrhoeic adolescents had higher mean LH, androstenedione, testosterone, DHEAS and oestradiol concentrations compared with girls with regular cycles. Fifty-seven percent of the oligomenorrhoeic girls had LH or androgen concentrations above the 95th percentile of adolescents with regular cycles. None of the 52-oligomenorrhoeic girls and only 1 of 4 girls with secondary amenorrhoea had a hypogonadotrophic endocrine pattern. This study supports the view that oligomenorrhoea in adolescents is not a stage in the physiological maturation of the hypothalamic pituitary-ovarian axis but an early sign of PCOS associated with subfertility. Physicians should consider endocrine evaluation before reassuring oligomenorrhoeic girls or prescribing oral contraceptives.

 

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