#1 Cost efficient IVF service and education in U.S. Outpatient based IVF. Complete facilities include ultrasound suite,endocrine and andrology labs, and all IVF facilities. Located at new outpatient therapy center offering the latest in laparoscopy and hysteroscopy. Accomodations for visitors are nearby, safe, and inexpensive.
Gonal F vs. Puregon
Title: Comparison of two recombinant follicle-stimulating hormone
preparations in in-vitro
fertilization: a randomized clinical study
Author: M. Tulppala, et al.
Address: Helsinki, Finland
Source: Human Reproduction 14: 2709-2715 (November) 1999
Summary: A randomized comparison of Gonal-F and Puregon in ovarian
stimulation for in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) was carried out on
348 women aged 22-43 years who were suffering from infertility due to miscellaneous causes. The
subjects underwent stimulation using equal starting doses (150 IU/day: Gonal-F n-164, Puregon n=158 or 300
IU/day: Gonal-F n=8, Puregon n=14) after down-regulation with intranasal buserelin from the mid-luteal
phase. Similar clinical pregnancy rates were achieved with both preparations; 33.5& per cycle and 37.4%
per embryo transfer with Gonal-F (150 IU/day) and 32.9% per cycle and 36.4% per embryo transfer with
Puregon (150 IU/day). The ongoing cumulative pregnancy rates after frozen-thawed embryo
transfer were 35.4% with Gonal-F and 37.7% with Puregon. Similar numbers of oocytes were obtained in both
groups. The fertilization and cleavage rates and the incidence of moderate or severe ovarian
hyperstimulation syndrome were also similar. Researchers concluded that Gonal-F and Puregon were equally
and highly effective in stimulation for IVF and ICSI.
HOME | The
Learning Center