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Caffeine and spontaneous abortion
Title:Maternal serum paraxanthine, a caffeine metabolite, and the
risk of spontaneous abortion
Author: M. Klebanoff, et al.
Address: Bethesda, Maryland
Source: The New England Journal of Medicine 341: 1639-1644 (November)
1999
Summary:In a nested case control study, researchers measured serum
paraxanthine in 591 women who had spontaneous abortions at <140 days' gestation
and in 2558 matched women who gave birth to live infants at >28 weeks' gestation.
Both groups had serum drawn on the same day of gestation. The women were enrolled
in the Collaborative Perinatal Project from 1959 - 1966, and serum paraxanthine
was measured over 30 years later. 487 women had spontaneous abortions (82%) and
2087 controls (82%) had quantifiable serum paraxanthine concentrations. The mean
serum paraxanthine concentration was higher in the women who had spontaneous
abortions than in the controls (752 vs 583 ng per milliliter). The odds ratio for
spontaneous abortion was not significantly elevated in the women who had serum
paraxanthine concentrations <1845 ng per milliliter. The adjusted odds ratio for
spontaneous abortion among women with serum paraxanthine concentrations >1845 ng
per milliliter, as compared with women who had concentrations below 50 ng per
milliliter, was 1.9. Researchers concluded that only extremely high serum
paraxanthine concentrations are associated with spontaneous abortion.
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